A 2025 study released in PubMed highlights the significant burden severe asthma places on patients, emphasizing overlooked needs beyond physical symptoms. It examines four key issues: fatigue, sleep disturbances, physical inactivity, and reduced work productivity. Fatigue affects up to 90% of patients, while sleep disturbances impact 70-75%, both impairing daily function and quality of life. Physical inactivity both results from and contributes to poor asthma control, whereas interventions promoting activity improve outcomes. Work productivity loss is closely tied to asthma severity, with biological therapies potentially mitigating its effects. The review calls for further research on both pharmacological and nonpharmacological interventions, such as pulmonary rehabilitation and behavioral therapies, to enhance patient well-being.
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